A Comparison Study of Multi-Objective Metaheuristic Techniques for Continuous Review Stochastic Inventory System

Supply chain management which involves managing the flow of material andinformation from sources to customers has been one of the most challenging issuesfacing both the academicians and the practitioners for years. Inventory control is acrucial part of tactical decision level affecting the performance of supply chain indistribution and production. The main focus of this study is to compare theperformance of different multi-objective metaheuristic techniques to optimizeinventory parameters for single-product continuous review stochastic inventorysystem with transportation costs. The simulation-based optimization method is usedto solve the problem by combining the simulation model and metaheuristicalgorithms in order to determine the inventory policy taking into account twoconflicting objectives: customer service level and total inventory cost. We build adiscrete event simulation model to evaluate the objective function of the problem.The Metaheuristic techniques such as the genetic algorithm and particle swarmoptimization are applied to search the solution space. The results obtained by allthese proposed techniques are compared and the effectiveness of each technique hasbeen illustrated

Pokeweed (Phytolacca americana L.) antiviral protein inhibits Zucchini yellow mosaic virus infection in a dose-dependent manner in squash plants

[EN] Pokeweed antiviral protein (PAP) of Phytolacca americana L. (pokeweed) is a single-chain ribosome-inactivating protein (RIP) characterized by its ability to depurinate plant ribosomes. Here, we isolated, cloned, and expressed the ribosome inactivating protein (RIP) gene, designated as pokeweed antiviral protein type 1 (PAP I), from the summer leaves of pokeweed collected from the Black Sea region (Turkey). Our findings presented here provide direct evidence that exogenous application of PAP I causes concentration-dependent inhibition of Zucchini yellow mosaic virus (ZYMV) infection on squash plants. Squash plants were exposed to PAP I protein with and without DMSO for four consecutive days. Regular spraying of approximately 30 kDa recombinant PAP I at 2 µg mL¿1 concentration prevented treated plants from mechanical virus infection. PAP I showed antiviral activity in 9 plants out of 15 inoculated plants. Remarkably, simultaneous application of PAP, DMSO, and ZYMV did not prevent virus infection, suggesting that PAP did not have any effect on viral RNA. In the absence of ZYMV the purified peptide was not cytotoxic for squash plants, although a reduction of plant size, possibly caused by host ribosome depurination, was observed.Financial support for this study was provided by the Scientific and Technological Research Council of Turkey (TUBITAK Project No: 110 O 180).Sipahioglu, HM.; Kaya, I.; Usta, M.; Unal, M.; Ozcan, D.; Ozer, M.; Guller, A.... (2017). Pokeweed (Phytolacca americana L.) antiviral protein inhibits Zucchini yellow mosaic virus infection in a dose-dependent manner in squash plants. Turkish Journal of Agriculture and Forestry. 41(4):256-262. https://doi.org/10.3906/tar-1612-30S25626241

Middle-term outcomes in renal transplant recipients with COVID-19: a national, multicenter, controlled study

Background In this study, we evaluated 3-month clinical outcomes of kidney transplant recipients (KTR) recovering from COVID-19 and compared them with a control group. Method The primary endpoint was death in the third month. Secondary endpoints were ongoing respiratory symptoms, need for home oxygen therapy, rehospitalization for any reason, lower respiratory tract infection, urinary tract infection, biopsy-proven acute rejection, venous/arterial thromboembolic event, cytomegalovirus (CMV) infection/disease and BK viruria/viremia at 3 months. Results A total of 944 KTR from 29 different centers were included in this study (523 patients in the COVID-19 group; 421 patients in the control group). The mean age was 46 +/- 12 years (interquartile range 37-55) and 532 (56.4%) of them were male. Total number of deaths was 8 [7 (1.3%) in COVID-19 group, 1 (0.2%) in control group; P = 0.082]. The proportion of patients with ongoing respiratory symptoms [43 (8.2%) versus 4 (1.0%); P Conclusion The prevalence of ongoing respiratory symptoms increased in the first 3 months post-COVID in KTRs who have recovered from COVID-19, but mortality was not significantly different